A nursing baby could develop diarrhea if the mother takes lubiprostone while breastfeeding. Ask your doctor about any risk, and tell your doctor if the baby develops diarrhea.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
You may have tightness in your chest or feel short of breath within 1 hour after taking lubiprostone. This side effect should go away within 3 hours, but it may occur again when you take your next dose.
Talk with your doctor if this side effect becomes bothersome. Do not take lubiprostone if you have severe diarrhea. Call your doctor for instructions. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat.
You may have low blood pressure and feel faint shortly after taking lubiprostone, especially if you've been sick with vomiting or diarrhea. Stop taking lubiprostone and call your doctor if you feel light-headed after every dose. This is not a complete list of side effects and others may occur. This is sometimes referred to as OIC, opioid-induced constipation. Amitiza and Linzess are each only indicated for use in adults, and use in children and adolescents is not approved.
Only your doctor can decide if these medications are the right choice for your condition. A systematic review of 21 randomized controlled clinical trials compared the active ingredients of Amitiza, Linzess, and other common constipation treatments.
Other treatments included in this study were prucalopride, tegaserod, bisacodyl, and polyethylene glycol PEG. This analysis concluded that all included drugs showed similar efficacy over placebo when evaluating an endpoint of having 3 or more spontaneous bowel movements per week. Bisacodyl, an over-the-counter stimulant laxative, was superior to both Amitiza and Linzess in terms of change in the number of bowel movements per week.
Stimulant laxatives may cause electrolyte imbalances and are prone to the development of tolerance over time. A prescriber may need to consider factors such as adverse events, drug interactions, and compliance with once daily or twice daily dosing when deciding which drug is best for a patient.
Amitiza is typically covered by both commercial and Medicare Part D drug plans, though in some cases it may also require prior approval for coverage. Linzess is typically covered by both commercial and Medicare Part D drug plans, though in some cases it may also require prior approval for coverage. Get the pharmacy discount card.
Amitiza and Linzess have some common adverse events between them, but also some more unique to each drug. Diarrhea is the most common reason for treatment discontinuation for both drugs, and is a common side effect for both drugs. Amitiza is highly likely to cause nausea, occurring in almost one in every three patients who take the drug. This appears to happen more often if it is taken on an empty stomach.
Sometimes this nausea is severe and debilitating, keeping patients from normal daily activities. Patients on Amitiza reported adverse events such as dizziness, fatigue, and chest pain, whereas patients on Linzess did not report these side effects. This is not intended to be a comprehensive list of adverse effects, please consult your doctor or pharmacist for a complete list.
Amitiza and Linzess should be used with caution in patients on drugs with anticholinergic properties. Anticholinergic drugs may promote constipation and oppose the pharmacologic actions of Amitiza and Linzess.
Abdominal pain, bloating and altered bowel habit significantly affect patient's quality of Abdominal pain, bloating and altered bowel habit significantly affect patients' quality of The findings might help explain why IBS is more common in women than in Print Email Share. Boy or Girl? Just a Game? Living Well. View all the latest top news in the environmental sciences, or browse the topics below:.
In three clinical studies that looked at Amitiza use in people with OIC, some had increased bowel movements. If your child shows signs of constipation, talk with their doctor about medications or other treatments that could help relieve it.
However, it does cause the same effects that these other treatments cause. It increases fluid levels in your intestines, which helps to pass stool. Chloride channels are found in most cells throughout your body. In your gastrointestinal tract, these channels play an important role in transporting fluid.
Amitiza activates these channels, which increases the amount of fluid in your intestines. The increased fluid helps your body to pass stool. Other drugs are available that can treat different types of constipation. Some may be better suited for you than others.
These drugs allow water and fats to enter the stool, which makes it easier to pass. Examples of stool softeners include:. These drugs help stimulate constriction tightening and relaxation of the muscles of your intestines.
This action helps move stool through the intestines. These drugs work by drawing more water into your intestines. This helps to soften the stool and make it easier to pass. These drugs work by keeping water inside the intestines and the stool.
Opioids slow down your gastrointestinal tract and reduce fluid in your bowels. These effects can cause constipation. PAMORAs work by blocking the effects of opioids in certain parts of the body, including the gastrointestinal tract. Normally, your intestines move food through them by constricting tightening and relaxing the muscles in the walls of the intestines. When this activity slows down, constipation can occur. Selective serotonin-4 5-HT4 receptor agonists work by stimulating this action in your intestines.
An example of this drug is:. These medications work by increasing the amount of water in your intestines. This softens the stool, which helps it move through your intestines. These drugs work similarly to Amitiza, but they act on a different kind of protein. This helps to soften stool and make it easier to pass. Like selective serotonin-4 5-HT4 receptor agonists above , stimulant laxatives work by stimulating the muscles in your intestines. The laxatives cause the muscles to constrict and relax, which moves stool through your intestines.
These drugs work by absorbing water in your intestines and then swelling up. This increases the amount of stool, which stimulates your bowels to move. Examples of bulking agents include:. Examples of surfactants include:. These drugs work by increasing the amount of water in your intestines. Examples of osmotic agents include:. Stimulant laxatives work by stimulating the muscles in your intestines.
Amitiza is typically taken either once in the morning and once in the evening, or once daily. Your doctor will tell you how often you should take it and when. Take Amitiza with food and a full glass of water.
Taking Amitiza with a small meal can help lessen the risk of nausea, which can be a common side effect.
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